Development of effective anti-influenza drugs: congeners and conjugates – a review
Identifieur interne : 000095 ( Main/Exploration ); précédent : 000094; suivant : 000096Development of effective anti-influenza drugs: congeners and conjugates – a review
Auteurs : Jiun-Jie Shie [Taïwan] ; Jim-Min Fang [Taïwan]Source :
- Journal of Biomedical Science [ 1021-7770 ] ; 2019.
Abstract
Influenza is a long-standing health problem. For treatment of seasonal flu and possible pandemic infections, there is a need to develop new anti-influenza drugs that have good bioavailability against a broad spectrum of influenza viruses, including the resistant strains. Relenza™ (zanamivir), Tamiflu™ (the phosphate salt of oseltamivir), Inavir™ (laninamivir octanoate) and Rapivab™ (peramivir) are four anti-influenza drugs targeting the viral neuraminidases (NAs). However, some problems of these drugs should be resolved, such as oral availability, drug resistance and the induced cytokine storm. Two possible strategies have been applied to tackle these problems by devising congeners and conjugates. In this review, congeners are the related compounds having comparable chemical structures and biological functions, whereas conjugate refers to a compound having two bioactive entities joined by a covalent bond. The rational design of NA inhibitors is based on the mechanism of the enzymatic hydrolysis of the sialic acid (Neu5Ac)-terminated glycoprotein. To improve binding affinity and lipophilicity of the existing NA inhibitors, several methods are utilized, including conversion of carboxylic acid to ester prodrug, conversion of guanidine to acylguanidine, substitution of carboxylic acid with bioisostere, and modification of glycerol side chain. Alternatively, conjugating NA inhibitors with other therapeutic entity provides a synergistic anti-influenza activity; for example, to kill the existing viruses and suppress the cytokines caused by cross-species infection.
Url:
DOI: 10.1186/s12929-019-0567-0
PubMed: 31640786
PubMed Central: 6806523
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000233
- to stream Pmc, to step Curation: 000233
- to stream Pmc, to step Checkpoint: 000074
- to stream Ncbi, to step Merge: 001016
- to stream Ncbi, to step Curation: 001016
- to stream Ncbi, to step Checkpoint: 001016
- to stream Main, to step Merge: 000095
- to stream Main, to step Curation: 000095
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of effective anti-influenza drugs: congeners and conjugates – a review</title><author><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0633 743X</institution-id><institution-id institution-id-type="GRID">grid.482885.b</institution-id><institution>Institute of Chemistry, Academia Sinica,</institution></institution-wrap>Taipei, 115 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution>Department of Chemistry,</institution><institution>National Taiwan University,</institution></institution-wrap>Taipei, 106 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution>The Genomics Research Center, Academia Sinica,</institution></institution-wrap>Taipei, 115 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31640786</idno><idno type="pmc">6806523</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806523</idno><idno type="RBID">PMC:6806523</idno><idno type="doi">10.1186/s12929-019-0567-0</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000233</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000233</idno><idno type="wicri:Area/Pmc/Curation">000233</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000233</idno><idno type="wicri:Area/Pmc/Checkpoint">000074</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000074</idno><idno type="wicri:Area/Ncbi/Merge">001016</idno><idno type="wicri:Area/Ncbi/Curation">001016</idno><idno type="wicri:Area/Ncbi/Checkpoint">001016</idno><idno type="wicri:doubleKey">1021-7770:2019:Shie J:development:of:effective</idno><idno type="wicri:Area/Main/Merge">000095</idno><idno type="wicri:Area/Main/Curation">000095</idno><idno type="wicri:Area/Main/Exploration">000095</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Development of effective anti-influenza drugs: congeners and conjugates – a review</title><author><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0633 743X</institution-id><institution-id institution-id-type="GRID">grid.482885.b</institution-id><institution>Institute of Chemistry, Academia Sinica,</institution></institution-wrap>Taipei, 115 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author><author><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution>Department of Chemistry,</institution><institution>National Taiwan University,</institution></institution-wrap>Taipei, 106 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution>The Genomics Research Center, Academia Sinica,</institution></institution-wrap>Taipei, 115 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taipei</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Biomedical Science</title><idno type="ISSN">1021-7770</idno><idno type="eISSN">1423-0127</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Influenza is a long-standing health problem. For treatment of seasonal flu and possible pandemic infections, there is a need to develop new anti-influenza drugs that have good bioavailability against a broad spectrum of influenza viruses, including the resistant strains. Relenza™ (zanamivir), Tamiflu™ (the phosphate salt of oseltamivir), Inavir™ (laninamivir octanoate) and Rapivab™ (peramivir) are four anti-influenza drugs targeting the viral neuraminidases (NAs). However, some problems of these drugs should be resolved, such as oral availability, drug resistance and the induced cytokine storm. Two possible strategies have been applied to tackle these problems by devising congeners and conjugates. In this review, congeners are the related compounds having comparable chemical structures and biological functions, whereas conjugate refers to a compound having two bioactive entities joined by a covalent bond. The rational design of NA inhibitors is based on the mechanism of the enzymatic hydrolysis of the sialic acid (Neu5Ac)-terminated glycoprotein. To improve binding affinity and lipophilicity of the existing NA inhibitors, several methods are utilized, including conversion of carboxylic acid to ester prodrug, conversion of guanidine to acylguanidine, substitution of carboxylic acid with bioisostere, and modification of glycerol side chain. Alternatively, conjugating NA inhibitors with other therapeutic entity provides a synergistic anti-influenza activity; for example, to kill the existing viruses and suppress the cytokines caused by cross-species infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Das, K" uniqKey="Das K">K Das</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Syrj Nen, Rk" uniqKey="Syrj Nen R">RK Syrjänen</name></author><author><name sortKey="Jokinen, J" uniqKey="Jokinen J">J Jokinen</name></author><author><name sortKey="Ziegler, T" uniqKey="Ziegler T">T Ziegler</name></author><author><name sortKey="Sundman, J" uniqKey="Sundman J">J Sundman</name></author><author><name sortKey="Lahdenkari, M" uniqKey="Lahdenkari M">M Lahdenkari</name></author><author><name sortKey="Julkunen, I" uniqKey="Julkunen I">I Julkunen</name></author><author><name sortKey="Kilpi, Tm" uniqKey="Kilpi T">TM Kilpi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rajao, Ds" uniqKey="Rajao D">DS Rajão</name></author><author><name sortKey="Perez, Dr" uniqKey="Perez D">DR Pérez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name></author><author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name></author><author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name></author><author><name sortKey="Shu, B" uniqKey="Shu B">B Shu</name></author><author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name></author><author><name sortKey="Balish, A" uniqKey="Balish A">A Balish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name></author><author><name sortKey="Jin, Dy" uniqKey="Jin D">DY Jin</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jagger, Bw" uniqKey="Jagger B">BW Jagger</name></author><author><name sortKey="Wise, Hm" uniqKey="Wise H">HM Wise</name></author><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name></author><author><name sortKey="Walters, Ka" uniqKey="Walters K">KA Walters</name></author><author><name sortKey="Wills, Nm" uniqKey="Wills N">NM Wills</name></author><author><name sortKey="Xiao, Yl" uniqKey="Xiao Y">YL Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wise, Hm" uniqKey="Wise H">HM Wise</name></author><author><name sortKey="Foeglein, A" uniqKey="Foeglein A">A Foeglein</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name></author><author><name sortKey="Dalton, Rm" uniqKey="Dalton R">RM Dalton</name></author><author><name sortKey="Patel, S" uniqKey="Patel S">S Patel</name></author><author><name sortKey="Howard, W" uniqKey="Howard W">W Howard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreijtz, Jh" uniqKey="Kreijtz J">JH Kreijtz</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Shi, M" uniqKey="Shi M">M Shi</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Bourgeois, M" uniqKey="Bourgeois M">M Bourgeois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chambers, Bs" uniqKey="Chambers B">BS Chambers</name></author><author><name sortKey="Parkhouse, K" uniqKey="Parkhouse K">K Parkhouse</name></author><author><name sortKey="Ross, Tm" uniqKey="Ross T">TM Ross</name></author><author><name sortKey="Alby, K" uniqKey="Alby K">K Alby</name></author><author><name sortKey="Hensley, Se" uniqKey="Hensley S">SE Hensley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author><author><name sortKey="Sun, Q" uniqKey="Sun Q">Q Sun</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name></author><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Jia, Z" uniqKey="Jia Z">Z Jia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossman, Js" uniqKey="Rossman J">JS Rossman</name></author><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaymard, A" uniqKey="Gaymard A">A Gaymard</name></author><author><name sortKey="Le Briand, N" uniqKey="Le Briand N">N Le Briand</name></author><author><name sortKey="Frobert, E" uniqKey="Frobert E">E Frobert</name></author><author><name sortKey="Lina, B" uniqKey="Lina B">B Lina</name></author><author><name sortKey="Escuret, V" uniqKey="Escuret V">V Escuret</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, K" uniqKey="Das K">K Das</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, K" uniqKey="Das K">K Das</name></author><author><name sortKey="Aramini, Jm" uniqKey="Aramini J">JM Aramini</name></author><author><name sortKey="Ma, Lc" uniqKey="Ma L">LC Ma</name></author><author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name></author><author><name sortKey="Arnold, E" uniqKey="Arnold E">E Arnold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name></author><author><name sortKey="Sugaya, N" uniqKey="Sugaya N">N Sugaya</name></author><author><name sortKey="Hirotsu, N" uniqKey="Hirotsu N">N Hirotsu</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name></author><author><name sortKey="Hurt, Ac" uniqKey="Hurt A">AC Hurt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stouffer, Al" uniqKey="Stouffer A">AL Stouffer</name></author><author><name sortKey="Acharya, R" uniqKey="Acharya R">R Acharya</name></author><author><name sortKey="Salom, D" uniqKey="Salom D">D Salom</name></author><author><name sortKey="Levine, As" uniqKey="Levine A">AS Levine</name></author><author><name sortKey="Di Costanzo, L" uniqKey="Di Costanzo L">L Di Costanzo</name></author><author><name sortKey="Soto, Cs" uniqKey="Soto C">CS Soto</name></author><author><name sortKey="Tereshko, V" uniqKey="Tereshko V">V Tereshko</name></author><author><name sortKey="Nanda, V" uniqKey="Nanda V">V Nanda</name></author><author><name sortKey="Stayrook, S" uniqKey="Stayrook S">S Stayrook</name></author><author><name sortKey="Degrado, Wf" uniqKey="Degrado W">WF DeGrado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schnell, Jr" uniqKey="Schnell J">JR Schnell</name></author><author><name sortKey="Chou, Jj" uniqKey="Chou J">JJ Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barik, S" uniqKey="Barik S">S Barik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheu, Tg" uniqKey="Sheu T">TG Sheu</name></author><author><name sortKey="Fry, Am" uniqKey="Fry A">AM Fry</name></author><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name></author><author><name sortKey="Deyde, Vm" uniqKey="Deyde V">VM Deyde</name></author><author><name sortKey="Shwe, T" uniqKey="Shwe T">T Shwe</name></author><author><name sortKey="Bullion, L" uniqKey="Bullion L">L Bullion</name></author><author><name sortKey="Peebles, Pj" uniqKey="Peebles P">PJ Peebles</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Klimov, Ai" uniqKey="Klimov A">AI Klimov</name></author><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chamni, S" uniqKey="Chamni S">S Chamni</name></author><author><name sortKey="De Eknamkul, W" uniqKey="De Eknamkul W">W De-Eknamkul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fukao, K" uniqKey="Fukao K">K Fukao</name></author><author><name sortKey="Noshi, T" uniqKey="Noshi T">T Noshi</name></author><author><name sortKey="Yamamoto, A" uniqKey="Yamamoto A">A Yamamoto</name></author><author><name sortKey="Kitano, M" uniqKey="Kitano M">M Kitano</name></author><author><name sortKey="Ando, Y" uniqKey="Ando Y">Y Ando</name></author><author><name sortKey="Noda, T" uniqKey="Noda T">T Noda</name></author><author><name sortKey="Baba, K" uniqKey="Baba K">K Baba</name></author><author><name sortKey="Matsumoto, K" uniqKey="Matsumoto K">K Matsumoto</name></author><author><name sortKey="Higuchi, N" uniqKey="Higuchi N">N Higuchi</name></author><author><name sortKey="Ikeda, M" uniqKey="Ikeda M">M Ikeda</name></author><author><name sortKey="Shishido, T" uniqKey="Shishido T">T Shishido</name></author><author><name sortKey="Naito, A" uniqKey="Naito A">A Naito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laborda, P" uniqKey="Laborda P">P Laborda</name></author><author><name sortKey="Wang, Sy" uniqKey="Wang S">SY Wang</name></author><author><name sortKey="Voglmeir, J" uniqKey="Voglmeir J">J Voglmeir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moscona, A" uniqKey="Moscona A">A Moscona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunn, Cj" uniqKey="Dunn C">CJ Dunn</name></author><author><name sortKey="Goa, Kl" uniqKey="Goa K">KL Goa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheer, Sm" uniqKey="Cheer S">SM Cheer</name></author><author><name sortKey="Wagstaff, Aj" uniqKey="Wagstaff A">AJ Wagstaff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Cu" uniqKey="Kim C">CU Kim</name></author><author><name sortKey="Lew, W" uniqKey="Lew W">W Lew</name></author><author><name sortKey="Williams, Ma" uniqKey="Williams M">MA Williams</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Escarpe, Pa" uniqKey="Escarpe P">PA Escarpe</name></author><author><name sortKey="Mendel, Db" uniqKey="Mendel D">DB Mendel</name></author><author><name sortKey="Laver, Wg" uniqKey="Laver W">WG Laver</name></author><author><name sortKey="Stevens, Rc" uniqKey="Stevens R">RC Stevens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcclellan, K" uniqKey="Mcclellan K">K McClellan</name></author><author><name sortKey="Perry, Cm" uniqKey="Perry C">CM Perry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kubo, S" uniqKey="Kubo S">S Kubo</name></author><author><name sortKey="Tomozawa, T" uniqKey="Tomozawa T">T Tomozawa</name></author><author><name sortKey="Kakuta, M" uniqKey="Kakuta M">M Kakuta</name></author><author><name sortKey="Tokumitsu, A" uniqKey="Tokumitsu A">A Tokumitsu</name></author><author><name sortKey="Yamashita, M" uniqKey="Yamashita M">M Yamashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author><author><name sortKey="Sidwell, Rw" uniqKey="Sidwell R">RW Sidwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name></author><author><name sortKey="Fry, Am" uniqKey="Fry A">AM Fry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cass, Lmr" uniqKey="Cass L">LMR Cass</name></author><author><name sortKey="Efthymiopoulos, C" uniqKey="Efthymiopoulos C">C Efthymiopoulos</name></author><author><name sortKey="Bye, A" uniqKey="Bye A">A Bye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burch, J" uniqKey="Burch J">J Burch</name></author><author><name sortKey="Corbett, M" uniqKey="Corbett M">M Corbett</name></author><author><name sortKey="Stock, C" uniqKey="Stock C">C Stock</name></author><author><name sortKey="Nicholson, K" uniqKey="Nicholson K">K Nicholson</name></author><author><name sortKey="Elliot, Aj" uniqKey="Elliot A">AJ Elliot</name></author><author><name sortKey="Duffy, S" uniqKey="Duffy S">S Duffy</name></author><author><name sortKey="Westwood, M" uniqKey="Westwood M">M Westwood</name></author><author><name sortKey="Palmer, S" uniqKey="Palmer S">S Palmer</name></author><author><name sortKey="Stewart, L" uniqKey="Stewart L">L Stewart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikematsu, H" uniqKey="Ikematsu H">H Ikematsu</name></author><author><name sortKey="Kawai, N" uniqKey="Kawai N">N Kawai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Birnkrant, D" uniqKey="Birnkrant D">D Birnkrant</name></author><author><name sortKey="Cox, E" uniqKey="Cox E">E Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deyde, Vm" uniqKey="Deyde V">VM Deyde</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Bright, Ra" uniqKey="Bright R">RA Bright</name></author><author><name sortKey="Shaw, M" uniqKey="Shaw M">M Shaw</name></author><author><name sortKey="Smith, Cb" uniqKey="Smith C">CB Smith</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name></author><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Klimov, Ai" uniqKey="Klimov A">AI Klimov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayden, F" uniqKey="Hayden F">F Hayden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meijer, A" uniqKey="Meijer A">A Meijer</name></author><author><name sortKey="Lackenby, A" uniqKey="Lackenby A">A Lackenby</name></author><author><name sortKey="Hungnes, O" uniqKey="Hungnes O">O Hungnes</name></author><author><name sortKey="Lina, B" uniqKey="Lina B">B Lina</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van-der Werf</name></author><author><name sortKey="Schweiger, B" uniqKey="Schweiger B">B Schweiger</name></author><author><name sortKey="Opp, M" uniqKey="Opp M">M Opp</name></author><author><name sortKey="Paget, J" uniqKey="Paget J">J Paget</name></author><author><name sortKey="Van De Kassteele, J" uniqKey="Van De Kassteele J">J van-de Kassteele</name></author><author><name sortKey="Hay, A" uniqKey="Hay A">A Hay</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bloom, Jd" uniqKey="Bloom J">JD Bloom</name></author><author><name sortKey="Gong, Li" uniqKey="Gong L">LI Gong</name></author><author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name></author><author><name sortKey="Pizzorno, A" uniqKey="Pizzorno A">A Pizzorno</name></author><author><name sortKey="Bouhy, X" uniqKey="Bouhy X">X Bouhy</name></author><author><name sortKey="Boivin, G" uniqKey="Boivin G">G Boivin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burmeister, Wp" uniqKey="Burmeister W">WP Burmeister</name></author><author><name sortKey="Henrissat, B" uniqKey="Henrissat B">B Henrissat</name></author><author><name sortKey="Bosso, C" uniqKey="Bosso C">C Bosso</name></author><author><name sortKey="Cusack, S" uniqKey="Cusack S">S Cusack</name></author><author><name sortKey="Ruigrok, Rwh" uniqKey="Ruigrok R">RWH Ruigrok</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author><author><name sortKey="Wu, Wy" uniqKey="Wu W">WY Wu</name></author><author><name sortKey="Kok, Gb" uniqKey="Kok G">GB Kok</name></author><author><name sortKey="Pegg, Ms" uniqKey="Pegg M">MS Pegg</name></author><author><name sortKey="Dyason, Jc" uniqKey="Dyason J">JC Dyason</name></author><author><name sortKey="Jin, B" uniqKey="Jin B">B Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russell, Rj" uniqKey="Russell R">RJ Russell</name></author><author><name sortKey="Haire, Lf" uniqKey="Haire L">LF Haire</name></author><author><name sortKey="Stevens, Dj" uniqKey="Stevens D">DJ Stevens</name></author><author><name sortKey="Collins, Pj" uniqKey="Collins P">PJ Collins</name></author><author><name sortKey="Lin, Yp" uniqKey="Lin Y">YP Lin</name></author><author><name sortKey="Blackburn, Gm" uniqKey="Blackburn G">GM Blackburn</name></author><author><name sortKey="Hay, Aj" uniqKey="Hay A">AJ Hay</name></author><author><name sortKey="Gamblin, Sj" uniqKey="Gamblin S">SJ Gamblin</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Nr" uniqKey="Taylor N">NR Taylor</name></author><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Janakiraman, Mn" uniqKey="Janakiraman M">MN Janakiraman</name></author><author><name sortKey="White, Cl" uniqKey="White C">CL White</name></author><author><name sortKey="Laver, Wg" uniqKey="Laver W">WG Laver</name></author><author><name sortKey="Air, Gm" uniqKey="Air G">GM Air</name></author><author><name sortKey="Luo, M" uniqKey="Luo M">M Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Mz" uniqKey="Wang M">MZ Wang</name></author><author><name sortKey="Tai, Cy" uniqKey="Tai C">CY Tai</name></author><author><name sortKey="Mendel, Db" uniqKey="Mendel D">DB Mendel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Collins, Pj" uniqKey="Collins P">PJ Collins</name></author><author><name sortKey="Haire, Lf" uniqKey="Haire L">LF Haire</name></author><author><name sortKey="Lin, Yp" uniqKey="Lin Y">YP Lin</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Russell, Rj" uniqKey="Russell R">RJ Russell</name></author><author><name sortKey="Walker, Pa" uniqKey="Walker P">PA Walker</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author><author><name sortKey="Martin, Sr" uniqKey="Martin S">SR Martin</name></author><author><name sortKey="Hay, Aj" uniqKey="Hay A">AJ Hay</name></author><author><name sortKey="Gamblin, Sj" uniqKey="Gamblin S">SJ Gamblin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mckimm Breschkin, Jl" uniqKey="Mckimm Breschkin J">JL McKimm-Breschkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Proudfoot, Jr" uniqKey="Proudfoot J">JR Proudfoot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Widmer, N" uniqKey="Widmer N">N Widmer</name></author><author><name sortKey="Meylan, P" uniqKey="Meylan P">P Meylan</name></author><author><name sortKey="Ivanyuk, A" uniqKey="Ivanyuk A">A Ivanyuk</name></author><author><name sortKey="Aouri, M" uniqKey="Aouri M">M Aouri</name></author><author><name sortKey="Decosterd, La" uniqKey="Decosterd L">LA Decosterd</name></author><author><name sortKey="Buclin, T" uniqKey="Buclin T">T Buclin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Zy" uniqKey="Liu Z">ZY Liu</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name></author><author><name sortKey="Zhao, Lx" uniqKey="Zhao L">LX Zhao</name></author><author><name sortKey="Li, Yh" uniqKey="Li Y">YH Li</name></author><author><name sortKey="Shao, Hy" uniqKey="Shao H">HY Shao</name></author><author><name sortKey="Yi, H" uniqKey="Yi H">H Yi</name></author><author><name sortKey="You, Xf" uniqKey="You X">XF You</name></author><author><name sortKey="Li, Zr" uniqKey="Li Z">ZR Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, Sv" uniqKey="Gupta S">SV Gupta</name></author><author><name sortKey="Gupta, D" uniqKey="Gupta D">D Gupta</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name></author><author><name sortKey="Dahan, A" uniqKey="Dahan A">A Dahan</name></author><author><name sortKey="Tsume, Y" uniqKey="Tsume Y">Y Tsume</name></author><author><name sortKey="Hilfinger, J" uniqKey="Hilfinger J">J Hilfinger</name></author><author><name sortKey="Lee, Kd" uniqKey="Lee K">KD Lee</name></author><author><name sortKey="Amidon, Gl" uniqKey="Amidon G">GL Amidon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Jm" uniqKey="Miller J">JM Miller</name></author><author><name sortKey="Dahan, A" uniqKey="Dahan A">A Dahan</name></author><author><name sortKey="Gupta, D" uniqKey="Gupta D">D Gupta</name></author><author><name sortKey="Varghese, S" uniqKey="Varghese S">S Varghese</name></author><author><name sortKey="Amidon, Gl" uniqKey="Amidon G">GL Amidon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gould, Pl" uniqKey="Gould P">PL Gould</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cazzola, M" uniqKey="Cazzola M">M Cazzola</name></author><author><name sortKey="Testi, R" uniqKey="Testi R">R Testi</name></author><author><name sortKey="Matera, Mg" uniqKey="Matera M">MG Matera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Kc" uniqKey="Liu K">KC Liu</name></author><author><name sortKey="Lee, Ps" uniqKey="Lee P">PS Lee</name></author><author><name sortKey="Wang, Sy" uniqKey="Wang S">SY Wang</name></author><author><name sortKey="Cheng, Yse" uniqKey="Cheng Y">YSE Cheng</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Ph" uniqKey="Hsu P">PH Hsu</name></author><author><name sortKey="Chiu, Dc" uniqKey="Chiu D">DC Chiu</name></author><author><name sortKey="Wu, Kl" uniqKey="Wu K">KL Wu</name></author><author><name sortKey="Lee, Ps" uniqKey="Lee P">PS Lee</name></author><author><name sortKey="Jan, Jt" uniqKey="Jan J">JT Jan</name></author><author><name sortKey="Cheng, Yse" uniqKey="Cheng Y">YSE Cheng</name></author><author><name sortKey="Tsai, Kc" uniqKey="Tsai K">KC Tsai</name></author><author><name sortKey="Cheng, Tj" uniqKey="Cheng T">TJ Cheng</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudrawar, S" uniqKey="Rudrawar S">S Rudrawar</name></author><author><name sortKey="Dyason, Jc" uniqKey="Dyason J">JC Dyason</name></author><author><name sortKey="Rameix Welti, Ma" uniqKey="Rameix Welti M">MA Rameix-Welti</name></author><author><name sortKey="Rose, Fj" uniqKey="Rose F">FJ Rose</name></author><author><name sortKey="Kerry, Ps" uniqKey="Kerry P">PS Kerry</name></author><author><name sortKey="Russell, Rj" uniqKey="Russell R">RJ Russell</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author><author><name sortKey="Thomson, Rj" uniqKey="Thomson R">RJ Thomson</name></author><author><name sortKey="Naffakh, N" uniqKey="Naffakh N">N Naffakh</name></author><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amaro, Re" uniqKey="Amaro R">RE Amaro</name></author><author><name sortKey="Minh, Ddl" uniqKey="Minh D">DDL Minh</name></author><author><name sortKey="Cheng, Ls" uniqKey="Cheng L">LS Cheng</name></author><author><name sortKey="Lindstrom, Wm" uniqKey="Lindstrom W">WM Lindstrom</name></author><author><name sortKey="Olson, Aj" uniqKey="Olson A">AJ Olson</name></author><author><name sortKey="Lin, Jh" uniqKey="Lin J">JH Lin</name></author><author><name sortKey="Li, Ww" uniqKey="Li W">WW Li</name></author><author><name sortKey="Mccammon, Ja" uniqKey="Mccammon J">JA McCammon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Ch" uniqKey="Lin C">CH Lin</name></author><author><name sortKey="Chang, Tc" uniqKey="Chang T">TC Chang</name></author><author><name sortKey="Das, A" uniqKey="Das A">A Das</name></author><author><name sortKey="Fang, My" uniqKey="Fang M">MY Fang</name></author><author><name sortKey="Hung, Hc" uniqKey="Hung H">HC Hung</name></author><author><name sortKey="Hsu, Kc" uniqKey="Hsu K">KC Hsu</name></author><author><name sortKey="Yang, Jm" uniqKey="Yang J">JM Yang</name></author><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author><author><name sortKey="Mong, Kk" uniqKey="Mong K">KK Mong</name></author><author><name sortKey="Hsu, Ta" uniqKey="Hsu T">TA Hsu</name></author><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, A" uniqKey="Das A">A Das</name></author><author><name sortKey="Adak, Ak" uniqKey="Adak A">AK Adak</name></author><author><name sortKey="Ponnapalli, K" uniqKey="Ponnapalli K">K Ponnapalli</name></author><author><name sortKey="Lin, Ch" uniqKey="Lin C">CH Lin</name></author><author><name sortKey="Hsu, Kc" uniqKey="Hsu K">KC Hsu</name></author><author><name sortKey="Yang, Jm" uniqKey="Yang J">JM Yang</name></author><author><name sortKey="Hsu, Ta" uniqKey="Hsu T">TA Hsu</name></author><author><name sortKey="Lin, Cc" uniqKey="Lin C">CC Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Meng, Y" uniqKey="Meng Y">Y Meng</name></author><author><name sortKey="Xu, S" uniqKey="Xu S">S Xu</name></author><author><name sortKey="Shen, W" uniqKey="Shen W">W Shen</name></author><author><name sortKey="Meng, Z" uniqKey="Meng Z">Z Meng</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Ding, G" uniqKey="Ding G">G Ding</name></author><author><name sortKey="Huang, W" uniqKey="Huang W">W Huang</name></author><author><name sortKey="Xiao, W" uniqKey="Xiao W">W Xiao</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patani, Ga" uniqKey="Patani G">GA Patani</name></author><author><name sortKey="Lavoie, Ej" uniqKey="Lavoie E">EJ LaVoie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meanwell, Na" uniqKey="Meanwell N">NA Meanwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walop, Jn" uniqKey="Walop J">JN Walop</name></author><author><name sortKey="Boschman, Tac" uniqKey="Boschman T">TAC Boschman</name></author><author><name sortKey="Jacobs, J" uniqKey="Jacobs J">J Jacobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friebolin, H" uniqKey="Friebolin H">H Friebolin</name></author><author><name sortKey="Supp, M" uniqKey="Supp M">M Supp</name></author><author><name sortKey="Brossmer, R" uniqKey="Brossmer R">R Brossmer</name></author><author><name sortKey="Keilich, G" uniqKey="Keilich G">G Keilich</name></author><author><name sortKey="Ziegler, D" uniqKey="Ziegler D">D Ziegler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallimann, K" uniqKey="Wallimann K">K Wallimann</name></author><author><name sortKey="Vasella, A" uniqKey="Vasella A">A Vasella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Th" uniqKey="Chan T">TH Chan</name></author><author><name sortKey="Xin, Yc" uniqKey="Xin Y">YC Xin</name></author><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vavricka, Cj" uniqKey="Vavricka C">CJ Vavricka</name></author><author><name sortKey="Muto, C" uniqKey="Muto C">C Muto</name></author><author><name sortKey="Hasunuma, T" uniqKey="Hasunuma T">T Hasunuma</name></author><author><name sortKey="Kimura, Y" uniqKey="Kimura Y">Y Kimura</name></author><author><name sortKey="Araki, M" uniqKey="Araki M">M Araki</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author><author><name sortKey="Ohrui, H" uniqKey="Ohrui H">H Ohrui</name></author><author><name sortKey="Izumi, M" uniqKey="Izumi M">M Izumi</name></author><author><name sortKey="Kiyota, H" uniqKey="Kiyota H">H Kiyota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hadhazi, A" uniqKey="Hadhazi A">Á Hadházi</name></author><author><name sortKey="Pascolutti, M" uniqKey="Pascolutti M">M Pascolutti</name></author><author><name sortKey="Bailly, B" uniqKey="Bailly B">B Bailly</name></author><author><name sortKey="Dyason, Jc" uniqKey="Dyason J">JC Dyason</name></author><author><name sortKey="Borbas, A" uniqKey="Borbas A">A Borbás</name></author><author><name sortKey="Thomson, Rj" uniqKey="Thomson R">RJ Thomson</name></author><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hadhazi, A" uniqKey="Hadhazi A">Á Hadházi</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Bailly, B" uniqKey="Bailly B">B Bailly</name></author><author><name sortKey="Maggioni, A" uniqKey="Maggioni A">A Maggioni</name></author><author><name sortKey="Martin, G" uniqKey="Martin G">G Martin</name></author><author><name sortKey="Dirr, L" uniqKey="Dirr L">L Dirr</name></author><author><name sortKey="Dyason, Jc" uniqKey="Dyason J">JC Dyason</name></author><author><name sortKey="Thomson, Rj" uniqKey="Thomson R">RJ Thomson</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author><author><name sortKey="Borbas, A" uniqKey="Borbas A">A Borbás</name></author><author><name sortKey="Ve, T" uniqKey="Ve T">T Ve</name></author><author><name sortKey="Pascolutti, M" uniqKey="Pascolutti M">M Pascolutti</name></author><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ballatore, C" uniqKey="Ballatore C">C Ballatore</name></author><author><name sortKey="Huryn, Dm" uniqKey="Huryn D">DM Huryn</name></author><author><name sortKey="Smith, Ab" uniqKey="Smith A">AB Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schug, Ka" uniqKey="Schug K">KA Schug</name></author><author><name sortKey="Lindner, W" uniqKey="Lindner W">W Lindner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klenchin, Va" uniqKey="Klenchin V">VA Klenchin</name></author><author><name sortKey="Czyz, A" uniqKey="Czyz A">A Czyz</name></author><author><name sortKey="Goryshin, Iy" uniqKey="Goryshin I">IY Goryshin</name></author><author><name sortKey="Gradman, R" uniqKey="Gradman R">R Gradman</name></author><author><name sortKey="Lovell, S" uniqKey="Lovell S">S Lovell</name></author><author><name sortKey="Rayment, I" uniqKey="Rayment I">I Rayment</name></author><author><name sortKey="Reznikoff, Ws" uniqKey="Reznikoff W">WS Reznikoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shie, Jj" uniqKey="Shie J">JJ Shie</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author><author><name sortKey="Lai, Pt" uniqKey="Lai P">PT Lai</name></author><author><name sortKey="Wen, Wh" uniqKey="Wen W">WH Wen</name></author><author><name sortKey="Wang, Sy" uniqKey="Wang S">SY Wang</name></author><author><name sortKey="Cheng, Yse" uniqKey="Cheng Y">YSE Cheng</name></author><author><name sortKey="Tsai, Kc" uniqKey="Tsai K">KC Tsai</name></author><author><name sortKey="Yang, As" uniqKey="Yang A">AS Yang</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vasella, A" uniqKey="Vasella A">A Vasella</name></author><author><name sortKey="Wyler, R" uniqKey="Wyler R">R Wyler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M von Itzstein</name></author><author><name sortKey="Wu, Wy" uniqKey="Wu W">WY Wu</name></author><author><name sortKey="Jin, B" uniqKey="Jin B">B Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Lz" uniqKey="Lin L">LZ Lin</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shie, Jj" uniqKey="Shie J">JJ Shie</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author><author><name sortKey="Wang, Sy" uniqKey="Wang S">SY Wang</name></author><author><name sortKey="Tsai, Kc" uniqKey="Tsai K">KC Tsai</name></author><author><name sortKey="Cheng, Yse" uniqKey="Cheng Y">YSE Cheng</name></author><author><name sortKey="Yang, As" uniqKey="Yang A">AS Yang</name></author><author><name sortKey="Hsiao, Sc" uniqKey="Hsiao S">SC Hsiao</name></author><author><name sortKey="Su, Cy" uniqKey="Su C">CY Su</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Ca" uniqKey="Chen C">CA Chen</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo, Yw" uniqKey="Lo Y">YW Lo</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shie, Jj" uniqKey="Shie J">JJ Shie</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carbain, B" uniqKey="Carbain B">B Carbain</name></author><author><name sortKey="Collins, Pj" uniqKey="Collins P">PJ Collins</name></author><author><name sortKey="Callum, L" uniqKey="Callum L">L Callum</name></author><author><name sortKey="Martin, Sr" uniqKey="Martin S">SR Martin</name></author><author><name sortKey="Hay, Aj" uniqKey="Hay A">AJ Hay</name></author><author><name sortKey="Mccauley, J" uniqKey="Mccauley J">J McCauley</name></author><author><name sortKey="Streicher, H" uniqKey="Streicher H">H Streicher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gunasekera, Ds" uniqKey="Gunasekera D">DS Gunasekera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, Ac" uniqKey="Schmidt A">AC Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woods, As" uniqKey="Woods A">AS Woods</name></author><author><name sortKey="Ferre, S" uniqKey="Ferre S">S Ferré</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pantos, A" uniqKey="Pantos A">A Pantos</name></author><author><name sortKey="Tsogas, I" uniqKey="Tsogas I">I Tsogas</name></author><author><name sortKey="Paleos, Cm" uniqKey="Paleos C">CM Paleos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stanley, M" uniqKey="Stanley M">M Stanley</name></author><author><name sortKey="Cattle, N" uniqKey="Cattle N">N Cattle</name></author><author><name sortKey="Mccauley, J" uniqKey="Mccauley J">J McCauley</name></author><author><name sortKey="Rashid, M" uniqKey="Rashid M">M Rashid</name></author><author><name sortKey="Field, Ar" uniqKey="Field A">AR Field</name></author><author><name sortKey="Carbain, B" uniqKey="Carbain B">B Carbain</name></author><author><name sortKey="Streicher, H" uniqKey="Streicher H">H Streicher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Tj" uniqKey="Cheng T">TJ Cheng</name></author><author><name sortKey="Weinheimer, S" uniqKey="Weinheimer S">S Weinheimer</name></author><author><name sortKey="Tarbet, Eb" uniqKey="Tarbet E">EB Tarbet</name></author><author><name sortKey="Jan, Jt" uniqKey="Jan J">JT Jan</name></author><author><name sortKey="Cheng, Ys" uniqKey="Cheng Y">YS Cheng</name></author><author><name sortKey="Shie, Jj" uniqKey="Shie J">JJ Shie</name></author><author><name sortKey="Chen, Cl" uniqKey="Chen C">CL Chen</name></author><author><name sortKey="Chen, Ca" uniqKey="Chen C">CA Chen</name></author><author><name sortKey="Hsieh, Wc" uniqKey="Hsieh W">WC Hsieh</name></author><author><name sortKey="Huang, Pw" uniqKey="Huang P">PW Huang</name></author><author><name sortKey="Lin, Wh" uniqKey="Lin W">WH Lin</name></author><author><name sortKey="Wang, Sy" uniqKey="Wang S">SY Wang</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author><author><name sortKey="Hu, Oy" uniqKey="Hu O">OY Hu</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Pc" uniqKey="Wang P">PC Wang</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author><author><name sortKey="Tsai, Kc" uniqKey="Tsai K">KC Tsai</name></author><author><name sortKey="Wang, Sy" uniqKey="Wang S">SY Wang</name></author><author><name sortKey="Huang, Wi" uniqKey="Huang W">WI Huang</name></author><author><name sortKey="Tseng, Yc" uniqKey="Tseng Y">YC Tseng</name></author><author><name sortKey="Cheng, Yse" uniqKey="Cheng Y">YSE Cheng</name></author><author><name sortKey="Cheng, Tjr" uniqKey="Cheng T">TJR Cheng</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Udommaneethanakit, T" uniqKey="Udommaneethanakit T">T Udommaneethanakit</name></author><author><name sortKey="Rungrotmongkol, T" uniqKey="Rungrotmongkol T">T Rungrotmongkol</name></author><author><name sortKey="Bren, U" uniqKey="Bren U">U Bren</name></author><author><name sortKey="Frecer, V" uniqKey="Frecer V">V Frecer</name></author><author><name sortKey="Stanislav, M" uniqKey="Stanislav M">M Stanislav</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Bj" uniqKey="Smith B">BJ Smith</name></author><author><name sortKey="Mckimm Breshkin, Jl" uniqKey="Mckimm Breshkin J">JL McKimm-Breshkin</name></author><author><name sortKey="Mcdonald, M" uniqKey="Mcdonald M">M McDonald</name></author><author><name sortKey="Fernley, Rt" uniqKey="Fernley R">RT Fernley</name></author><author><name sortKey="Varghese, Jn" uniqKey="Varghese J">JN Varghese</name></author><author><name sortKey="Colman, Pm" uniqKey="Colman P">PM Colman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurt, Ac" uniqKey="Hurt A">AC Hurt</name></author><author><name sortKey="Holien, Jk" uniqKey="Holien J">JK Holien</name></author><author><name sortKey="Parker, Mw" uniqKey="Parker M">MW Parker</name></author><author><name sortKey="Barr, Ig" uniqKey="Barr I">IG Barr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Bt" uniqKey="Hong B">BT Hong</name></author><author><name sortKey="Cheng, Yse" uniqKey="Cheng Y">YSE Cheng</name></author><author><name sortKey="Cheng, Tj" uniqKey="Cheng T">TJ Cheng</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sollis, Sl" uniqKey="Sollis S">SL Sollis</name></author><author><name sortKey="Smith, Pw" uniqKey="Smith P">PW Smith</name></author><author><name sortKey="Howes, Pd" uniqKey="Howes P">PD Howes</name></author><author><name sortKey="Cherry, Pc" uniqKey="Cherry P">PC Cherry</name></author><author><name sortKey="Bethell, Rc" uniqKey="Bethell R">RC Bethell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Pw" uniqKey="Smith P">PW Smith</name></author><author><name sortKey="Sollis, Sl" uniqKey="Sollis S">SL Sollis</name></author><author><name sortKey="Howes, Pd" uniqKey="Howes P">PD Howes</name></author><author><name sortKey="Cherry, Pc" uniqKey="Cherry P">PC Cherry</name></author><author><name sortKey="Starkey, Id" uniqKey="Starkey I">ID Starkey</name></author><author><name sortKey="Cobley, Kn" uniqKey="Cobley K">KN Cobley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Pw" uniqKey="Smith P">PW Smith</name></author><author><name sortKey="Sollis, Sl" uniqKey="Sollis S">SL Sollis</name></author><author><name sortKey="Howes, Pd" uniqKey="Howes P">PD Howes</name></author><author><name sortKey="Cherry, Pc" uniqKey="Cherry P">PC Cherry</name></author><author><name sortKey="Bethell, Rc" uniqKey="Bethell R">RC Bethell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Nr" uniqKey="Taylor N">NR Taylor</name></author><author><name sortKey="Cleasby, A" uniqKey="Cleasby A">A Cleasby</name></author><author><name sortKey="Singh, O" uniqKey="Singh O">O Singh</name></author><author><name sortKey="Skarzynski, T" uniqKey="Skarzynski T">T Skarzynski</name></author><author><name sortKey="Wonacott, Aj" uniqKey="Wonacott A">AJ Wonacott</name></author><author><name sortKey="Smith, Pw" uniqKey="Smith P">PW Smith</name></author><author><name sortKey="Sollis, Sl" uniqKey="Sollis S">SL Sollis</name></author><author><name sortKey="Howes, Pd" uniqKey="Howes P">PD Howes</name></author><author><name sortKey="Cherry, Pc" uniqKey="Cherry P">PC Cherry</name></author><author><name sortKey="Bethell, R" uniqKey="Bethell R">R Bethell</name></author><author><name sortKey="Colman, P" uniqKey="Colman P">P Colman</name></author><author><name sortKey="Varghese, J" uniqKey="Varghese J">J Varghese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varghese, Jn" uniqKey="Varghese J">JN Varghese</name></author><author><name sortKey="Epa, Vc" uniqKey="Epa V">VC Epa</name></author><author><name sortKey="Colman, Pm" uniqKey="Colman P">PM Colman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamashita, M" uniqKey="Yamashita M">M Yamashita</name></author><author><name sortKey="Tomozawa, T" uniqKey="Tomozawa T">T Tomozawa</name></author><author><name sortKey="Kakuta, M" uniqKey="Kakuta M">M Kakuta</name></author><author><name sortKey="Tokumitsu, A" uniqKey="Tokumitsu A">A Tokumitsu</name></author><author><name sortKey="Nau, H" uniqKey="Nau H">H Nau</name></author><author><name sortKey="Kubo, S" uniqKey="Kubo S">S Kubo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamashita, M" uniqKey="Yamashita M">M Yamashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishizuka, H" uniqKey="Ishizuka H">H Ishizuka</name></author><author><name sortKey="Yoshiba, S" uniqKey="Yoshiba S">S Yoshiba</name></author><author><name sortKey="Okabe, H" uniqKey="Okabe H">H Okabe</name></author><author><name sortKey="Yoshihara, K" uniqKey="Yoshihara K">K Yoshihara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrews, Dm" uniqKey="Andrews D">DM Andrews</name></author><author><name sortKey="Cherry, Pc" uniqKey="Cherry P">PC Cherry</name></author><author><name sortKey="Humber, Dc" uniqKey="Humber D">DC Humber</name></author><author><name sortKey="Jones, Ps" uniqKey="Jones P">PS Jones</name></author><author><name sortKey="Keeling, Sp" uniqKey="Keeling S">SP Keeling</name></author><author><name sortKey="Martin, Pf" uniqKey="Martin P">PF Martin</name></author><author><name sortKey="Shaw, Cd" uniqKey="Shaw C">CD Shaw</name></author><author><name sortKey="Swanson, S" uniqKey="Swanson S">S Swanson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frantz, S" uniqKey="Frantz S">S Frantz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morphy, R" uniqKey="Morphy R">R Morphy</name></author><author><name sortKey="Rankovic, Z" uniqKey="Rankovic Z">Z Rankovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Medina Franco, Jl" uniqKey="Medina Franco J">JL Medina-Franco</name></author><author><name sortKey="Giulianotti, Ma" uniqKey="Giulianotti M">MA Giulianotti</name></author><author><name sortKey="Welmaker, Gs" uniqKey="Welmaker G">GS Welmaker</name></author><author><name sortKey="Houghten, Ra" uniqKey="Houghten R">RA Houghten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonnett, R" uniqKey="Bonnett R">R Bonnett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macdonal, Ij" uniqKey="Macdonal I">IJ Macdonal</name></author><author><name sortKey="Dougherty, Tj" uniqKey="Dougherty T">TJ Dougherty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castano, Ap" uniqKey="Castano A">AP Castano</name></author><author><name sortKey="Demidova, Tn" uniqKey="Demidova T">TN Demidova</name></author><author><name sortKey="Hambline, Mr" uniqKey="Hambline M">MR Hambline</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berthiaume, F" uniqKey="Berthiaume F">F Berthiaume</name></author><author><name sortKey="Reiken, Sr" uniqKey="Reiken S">SR Reiken</name></author><author><name sortKey="Toner, M" uniqKey="Toner M">M Toner</name></author><author><name sortKey="Tompkins, Rg" uniqKey="Tompkins R">RG Tompkins</name></author><author><name sortKey="Yarmush, Ml" uniqKey="Yarmush M">ML Yarmush</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wainwright, M" uniqKey="Wainwright M">M Wainwright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamblin, Mr" uniqKey="Hamblin M">MR Hamblin</name></author><author><name sortKey="Hasan, T" uniqKey="Hasan T">T Hasan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wen, Wh" uniqKey="Wen W">WH Wen</name></author><author><name sortKey="Lin, M" uniqKey="Lin M">M Lin</name></author><author><name sortKey="Su, Cy" uniqKey="Su C">CY Su</name></author><author><name sortKey="Wang, Sy" uniqKey="Wang S">SY Wang</name></author><author><name sortKey="Cheng, Ys" uniqKey="Cheng Y">YS Cheng</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Yc" uniqKey="Lee Y">YC Lee</name></author><author><name sortKey="Lee, Rt" uniqKey="Lee R">RT Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mammen, M" uniqKey="Mammen M">M Mammen</name></author><author><name sortKey="Dahmann, G" uniqKey="Dahmann G">G Dahmann</name></author><author><name sortKey="Whitesides, Gm" uniqKey="Whitesides G">GM Whitesides</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mammen, M" uniqKey="Mammen M">M Mammen</name></author><author><name sortKey="Choi, Sk" uniqKey="Choi S">SK Choi</name></author><author><name sortKey="Whitesides, Gm" uniqKey="Whitesides G">GM Whitesides</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lundquist, Jj" uniqKey="Lundquist J">JJ Lundquist</name></author><author><name sortKey="Toone, Ej" uniqKey="Toone E">EJ Toone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macdonald, Sj" uniqKey="Macdonald S">SJ Macdonald</name></author><author><name sortKey="Watson, Kg" uniqKey="Watson K">KG Watson</name></author><author><name sortKey="Cameron, R" uniqKey="Cameron R">R Cameron</name></author><author><name sortKey="Chalmers, Dk" uniqKey="Chalmers D">DK Chalmers</name></author><author><name sortKey="Demaine, Da" uniqKey="Demaine D">DA Demaine</name></author><author><name sortKey="Fenton, Rj" uniqKey="Fenton R">RJ Fenton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watson, Kg" uniqKey="Watson K">KG Watson</name></author><author><name sortKey="Cameron, R" uniqKey="Cameron R">R Cameron</name></author><author><name sortKey="Fenton, Rj" uniqKey="Fenton R">RJ Fenton</name></author><author><name sortKey="Gower, D" uniqKey="Gower D">D Gower</name></author><author><name sortKey="Hamilton, S" uniqKey="Hamilton S">S Hamilton</name></author><author><name sortKey="Jin, B" uniqKey="Jin B">B Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macdonald, Sj" uniqKey="Macdonald S">SJ Macdonald</name></author><author><name sortKey="Cameron, R" uniqKey="Cameron R">R Cameron</name></author><author><name sortKey="Demaine, Da" uniqKey="Demaine D">DA Demaine</name></author><author><name sortKey="Fenton, Rj" uniqKey="Fenton R">RJ Fenton</name></author><author><name sortKey="Foster, G" uniqKey="Foster G">G Foster</name></author><author><name sortKey="Gower, D" uniqKey="Gower D">D Gower</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fraser, Bh" uniqKey="Fraser B">BH Fraser</name></author><author><name sortKey="Hamilton, S" uniqKey="Hamilton S">S Hamilton</name></author><author><name sortKey="Krause Heuer, Am" uniqKey="Krause Heuer A">AM Krause-Heuer</name></author><author><name sortKey="Wright, Pj" uniqKey="Wright P">PJ Wright</name></author><author><name sortKey="Greguric, I" uniqKey="Greguric I">I Greguric</name></author><author><name sortKey="Tucke, Sp" uniqKey="Tucke S">SP Tucke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda, T" uniqKey="Honda T">T Honda</name></author><author><name sortKey="Masuda, T" uniqKey="Masuda T">T Masuda</name></author><author><name sortKey="Yoshida, S" uniqKey="Yoshida S">S Yoshida</name></author><author><name sortKey="Arai, M" uniqKey="Arai M">M Arai</name></author><author><name sortKey="Kobayashi, Y" uniqKey="Kobayashi Y">Y Kobayashi</name></author><author><name sortKey="Yamashita, M" uniqKey="Yamashita M">M Yamashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weight, Ak" uniqKey="Weight A">AK Weight</name></author><author><name sortKey="Haldar, J" uniqKey="Haldar J">J Haldar</name></author><author><name sortKey="Alvarez De Cienfuegos, L" uniqKey="Alvarez De Cienfuegos L">L Álvarez de Cienfuegos</name></author><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Klibanov, Am" uniqKey="Klibanov A">AM Klibanov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Cm" uniqKey="Lee C">CM Lee</name></author><author><name sortKey="Weight, Ak" uniqKey="Weight A">AK Weight</name></author><author><name sortKey="Haldar, J" uniqKey="Haldar J">J Haldar</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Klibanov, Am" uniqKey="Klibanov A">AM Klibanov</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haldar, J" uniqKey="Haldar J">J Haldar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Kc" uniqKey="Liu K">KC Liu</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author><author><name sortKey="Jan, Jt" uniqKey="Jan J">JT Jan</name></author><author><name sortKey="Cheng, Tj" uniqKey="Cheng T">TJ Cheng</name></author><author><name sortKey="Wang, Sy" uniqKey="Wang S">SY Wang</name></author><author><name sortKey="Yang, St" uniqKey="Yang S">ST Yang</name></author><author><name sortKey="Cheng, Yse" uniqKey="Cheng Y">YSE Cheng</name></author><author><name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salomon, R" uniqKey="Salomon R">R Salomon</name></author><author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ottolini, M" uniqKey="Ottolini M">M Ottolini</name></author><author><name sortKey="Blanco, J" uniqKey="Blanco J">J Blanco</name></author><author><name sortKey="Porter, D" uniqKey="Porter D">D Porter</name></author><author><name sortKey="Peterson, L" uniqKey="Peterson L">L Peterson</name></author><author><name sortKey="Curtis, S" uniqKey="Curtis S">S Curtis</name></author><author><name sortKey="Prince, G" uniqKey="Prince G">G Prince</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Chan, Kw" uniqKey="Chan K">KW Chan</name></author><author><name sortKey="Lin, Yp" uniqKey="Lin Y">YP Lin</name></author><author><name sortKey="Zhao, Gy" uniqKey="Zhao G">GY Zhao</name></author><author><name sortKey="Chan, C" uniqKey="Chan C">C Chan</name></author><author><name sortKey="Zhang, Hj" uniqKey="Zhang H">HJ Zhang</name></author><author><name sortKey="Chen, Hl" uniqKey="Chen H">HL Chen</name></author><author><name sortKey="Wong, Ss" uniqKey="Wong S">SS Wong</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Jin, Dy" uniqKey="Jin D">DY Jin</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babu, Ys" uniqKey="Babu Y">YS Babu</name></author><author><name sortKey="Chand, P" uniqKey="Chand P">P Chand</name></author><author><name sortKey="Bantia, S" uniqKey="Bantia S">S Bantia</name></author><author><name sortKey="Kotian, P" uniqKey="Kotian P">P Kotian</name></author><author><name sortKey="Dehghani, A" uniqKey="Dehghani A">A Dehghani</name></author><author><name sortKey="El Kattan, Y" uniqKey="El Kattan Y">Y El-Kattan</name></author><author><name sortKey="Lin, Th" uniqKey="Lin T">TH Lin</name></author><author><name sortKey="Hutchison, Tl" uniqKey="Hutchison T">TL Hutchison</name></author><author><name sortKey="Elliott, Aj" uniqKey="Elliott A">AJ Elliott</name></author><author><name sortKey="Parker, Cd" uniqKey="Parker C">CD Parker</name></author><author><name sortKey="Ananth, Sl" uniqKey="Ananth S">SL Ananth</name></author><author><name sortKey="Horn, Ll" uniqKey="Horn L">LL Horn</name></author><author><name sortKey="Laver, Gw" uniqKey="Laver G">GW Laver</name></author><author><name sortKey="Montgomery, Ja" uniqKey="Montgomery J">JA Montgomery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alame, Mm" uniqKey="Alame M">MM Alame</name></author><author><name sortKey="Massaad, E" uniqKey="Massaad E">E Massaad</name></author><author><name sortKey="Zaraket, H" uniqKey="Zaraket H">H Zaraket</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Pc" uniqKey="Wang P">PC Wang</name></author><author><name sortKey="Chiu, Dc" uniqKey="Chiu D">DC Chiu</name></author><author><name sortKey="Jan, Jt" uniqKey="Jan J">JT Jan</name></author><author><name sortKey="Huang, Wi" uniqKey="Huang W">WI Huang</name></author><author><name sortKey="Tseng, Yc" uniqKey="Tseng Y">YC Tseng</name></author><author><name sortKey="Li, Tt" uniqKey="Li T">TT Li</name></author><author><name sortKey="Cheng, Tj" uniqKey="Cheng T">TJ Cheng</name></author><author><name sortKey="Tsai, Kc" uniqKey="Tsai K">KC Tsai</name></author><author><name sortKey="Fang, Jm" uniqKey="Fang J">JM Fang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Shie, Jiun Jie" sort="Shie, Jiun Jie" uniqKey="Shie J" first="Jiun-Jie" last="Shie">Jiun-Jie Shie</name></noRegion><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name><name sortKey="Fang, Jim Min" sort="Fang, Jim Min" uniqKey="Fang J" first="Jim-Min" last="Fang">Jim-Min Fang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000095 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000095 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6806523
|texte= Development of effective anti-influenza drugs: congeners and conjugates – a review
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31640786" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |